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Hope my review helps not less than one fellow chilly sore sufferer! These carbonyl and hydroxyl oxygens have been proposed to facilitate the switch of the methyl group during catalysis 16 , 21 , 24 As well as, tyrosine residues within the lysine-binding clefts of SET7/9 (Tyr245 and Tyr305) and DIM-5 (Tyr178) [hydrogen-bond](http://www.mekuru7.leosv.com/2020/04/05/the-best-cam-sites-and-live-sex-cams-on-the-internet/) to the lysine ε-amino group, aligning it for a methyltransfer with AdoMet (Determine 4b,c ).
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