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The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of [histone](https://reellifegames.uk/a-christmas-full-of-wilds-slot-unwrap-the-wild-wins-now/) H3 and that are structurally not related to SET-domain proteins 4 - 6 Latest work suggests that SET-area-containing proteins methylate a couple of proteins along with histones (see later)

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