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[thekingsleyclinic.com](http://thekingsleyclinic.com/resources/understanding...)The exception to the rule is the DOT1 family, members of which methylate K79 in the globular area of histone H3 and that are structurally not related to SET-area proteins 4 - 6 Latest work means that SET-domain-containing proteins methylate just a few proteins along with histones (see later) |